TB5 ( BT5 ) TB500

Mechanism of Action

TB-500 is a synthetic version of the 43-amino acid naturally occurring peptide Thymosin Beta-4 (Tβ4). Its primary mechanism is regulation of actin polymerization — the fundamental process that controls cell structure, migration, and tissue repair. It also upregulates VEGF (angiogenesis), reduces pro-inflammatory cytokines (IL-1β, TNF-α), and promotes stem cell migration and differentiation.

Therapeutic Uses

• •Cardiac repair: Research shows reduced infarct size, improved ejection fraction, and promotion of cardiomyocyte survival after myocardial infarction.
• •Wound healing: Accelerates dermal wound closure 2-3x faster than control in animal models.
• •Corneal repair: Regenerx's RGN-259 (Tβ4 eye drops) completed Phase 3 trials for dry eye disease and neurotrophic keratopathy.
• •Musculoskeletal healing: Promotes muscle fiber repair, tendon healing, and reduces fibrotic scar formation.
• •Hair regrowth: Stimulates hair follicle stem cell migration and differentiation.
• •Neurological repair: Promotes oligodendrocyte differentiation and remyelination in CNS injury models.

Empirical Evidence

Bock-Marquette I et al. (Nature 2004) — Demonstrated cardiac protection and repair after MI. Smart N et al. (Nature 2007) — Tβ4 activates epicardial progenitor cells for cardiac regeneration. Regenerx Biopharmaceuticals — Phase 3 clinical trials for ophthalmic applications.