SMO5 Sermorelin Acetate

Mechanism of Action

Sermorelin is the 29-amino acid N-terminal fragment of endogenous GHRH(1-44) — containing the full biologically active portion. It preserves natural negative feedback loops, meaning the body's own regulatory systems remain intact. Half-life is approximately 10-20 minutes, producing pulsatile GH release that closely mimics natural physiology.

Therapeutic Uses

• •GH deficiency (pediatric): FDA-approved as Geref® for diagnostic testing and treatment of pediatric GH deficiency.
• •Age-related GH decline: The most studied GHRH peptide for anti-aging applications with 20+ years of clinical safety data.
• •GH axis assessment: Used as a diagnostic tool to differentiate pituitary vs hypothalamic causes of GH deficiency.

Empirical Evidence

FDA-approved with extensive Phase 3 data. 20+ years of clinical safety data. Prakash A, Goa KL (BioDrugs 1999) — Comprehensive review confirming efficacy and safety. Significant GH and IGF-1 elevation with preservation of natural feedback.