NJ100 NAD+

Mechanism of Action

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme participating in 500+ enzymatic reactions. It is the primary substrate for sirtuins (SIRT1-7, the 'longevity genes'), PARPs (DNA repair enzymes), and CD38 (immune signaling). NAD+ levels decline approximately 50% between ages 20-60.

Therapeutic Uses

• •Age-related decline: Directly addresses the NAD+ deficit, restoring sirtuin activity and DNA repair capacity.
• •Cognitive function / neurodegeneration: NAD+ is essential for neuronal health. Studied for neuroprotective effects in Alzheimer's and Parkinson's models.
• •Metabolic health: Improves insulin sensitivity, mitochondrial function, and metabolic rate.
• •Addiction recovery: IV NAD+ therapy is used by some clinics for addiction detoxification and withdrawal management.
• •Athletic recovery: Supports cellular energy production and repair mechanisms.

Empirical Evidence

Imai S, Guarente L (Trends Cell Biol 2014) — Comprehensive review of NAD+ decline in aging. Harvard studies (Sinclair DA) — Restoring NAD+ reversed many markers of aging in mice. Human studies — 40-90% increase in blood NAD+ levels with supplementation.